4-(Gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase
4-(gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase (EC 1.14.14.13, btrO (gene)) is an enzyme with systematic name 4-(gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein),FMN:oxygen oxidoreductase (2-hydroxylating).[1] This enzyme catalyses the following chemical reaction
| 4-(gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.13 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] + FMNH2 + O2 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] + FMN + H2O
4-(gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase catalyses a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family.
References edit
- ^ Li Y, Llewellyn NM, Giri R, Huang F, Spencer JB (June 2005). "Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway". Chemistry & Biology. 12 (6): 665–75. doi:10.1016/j.chembiol.2005.04.010. PMID 15975512.
External links edit
- 4-(gamma-L-glutamylamino)butanoyl-(BtrI+acyl-carrier+protein)+monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
