3-(Trifluoromethyl)aniline is an organic compound with the formula CF3C6H4NH2. It is one of three isomers of trifluoromethylaniline. Classified as an aromatic amines, they are colorless liquids. The corresponding dimethylamino derivative is also known.[1]
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Preferred IUPAC name
3-(Trifluoromethyl)aniline | |
Other names
3-Aminobenzotrifluoride; m-ABTF; m-Trifluoromethylaniline, 3-(Trifluoromethyl)phenyl-1-amine
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.002.404 |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C7H6F3N | |
Molar mass | 161.12 g/mol |
Density | 1.29 g/cm3 |
Melting point | 5 to 6 °C (41 to 43 °F; 278 to 279 K) |
Boiling point | 187 to 188 °C (369 to 370 °F; 460 to 461 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Drugs List
editUsed in the following list of Drugs:
- Atovaquone
- Colfenamate
- Etofenamate
- Floctafenine
- Flufenamic acid
- HT-2157
- Losulazine
- Morniflumate
- Niflumic acid
- Norflurazon
- Pentflutizide
- Prefenamate
- Salfluverine
- Talniflumate
- Triflocin
- Ticarbodine
- Ufenamate
Also used in the synthesis of 4-Chloro-7-(trifluoromethyl)quinoline [346-55-4] intermediate:
- Antrafenine
- EHT-1864
- Florifenine
- Losulazine
- Trifluoroquine
- PC13544868[2] (antihypertensive)
References
edit- ^ William A. Sheppard (1969). "m-Trifluoromethyl-N,N-Dimethylaniline". Organic Syntheses. 49: 111. doi:10.15227/orgsyn.049.0111.
- ^ John M. McCall, U.S. patent 4,140,775 (1979 to Pharmacia and Upjohn Co).