Date | Time | Opponent | Site | TV | Result | Attendance |
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September 2 | 7:00 p.m. | Virginia* | | ESPNU | W 38–13 | 46,758 |
September 8 | 8:00 p.m. | at Cincinnati | | ESPN2 | W 33–15 | 20,611 |
September 16 | 12:00 p.m. | Michigan State* | - Heinz Field
- Pittsburgh, PA
| ABC | L 23–38 | 47,956 |
September 23 | 1:30 p.m. | The Citadel* | - Heinz Field
- Pittsburgh, PA
| ESPN360 | W 51–6 | 30,069 |
September 30 | 12:00 p.m. | Toledo* | - Heinz Field
- Pittsburgh, PA
| ESPNU | W 45–3 | 31,212 |
October 7 | 12:00 p.m. | at Syracuse | | ESPN+ | W 21–11 | 41,870 |
October 13 | 8:00 p.m. | at UCF* | | ESPN | W 52–7 | 35,858 |
October 21 | 5:45 p.m. | No. 15 Rutgers | - Heinz Field
- Pittsburgh, PA
| ESPN2 | L 10–20 | 49,620 |
November 4 | 12:00 p.m. | at South Florida | | ESPN+ | L 12–22 | 35,671 |
November 11 | 12:00 p.m. | at Connecticut | | ESPN+ | L 45–46 2OT | 40,000 |
November 16 | 7:30 p.m. | No. 8 West Virginia | | ESPN | L 27–45 | 55,642 |
November 25 | 3:30 p.m. | No. 8 Louisville | - Heinz Field
- Pittsburgh, PA
| ESPN | L 24–48 | 41,881 |
- *Non-conference game
- Homecoming
- Rankings from AP Poll released prior to the game
- All times are in Eastern time
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2006 Pittsburgh Panthers football staff
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Coaching staff
- Dave Wannstedt – Head coach
- Bob Junko – Assistant head coach/recruiting coordinator
- Matt Cavanaugh – Offensive coordinator/quarterbacks
- Paul Rhoads – Defensive coordinator/secondary
- Curtis Bray – Linebackers
- Paul Dunn – Offensive line
- Greg Gattuso – Defensive line
- Aubrey Hill – Receivers
- Charlie Partridge – Defensive line/special teams
- David Walker – Running backs
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Support staff
- Chris LaSala – Assistant Athletic Director/football operations
- Mike Antonoplos – Student-athlete development coordinator
- Brian Angelichio – Offensive graduate assistant/tight ends
- Jeff Hafley – Defensive graduate assistant/secondary
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Strength and conditioning staff
- Mike Kent – Strength and conditioning coach
- Darren Honeycutt – Assistant strength and conditioning coach
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Team players drafted into the NFL
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