The 1980–81 Algerian Cup is the 19th edition of the Algerian Cup. EP Sétif are the defending champions, having beaten USK Alger 1–0 in the previous season's final.
| كأس الجزائر | |
|---|---|
| Tournament details | |
| Country |  Algeria |
| Defending champions | EP Sétif (5) |
| Final positions | |
| Champions | USK Alger (1) |
| Runner-up | ASC Oran |
Round of 64 edit
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Round of 32 edit
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Round of 16 edit
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Quarter-finals edit
| 1981 | USK Alger | 1 – 0 | USM El Harrach | Stade 20 Août 1955, Algiers |
| 1981 | MP Oran | 2 – 1 | IRB Madania |
| 1981 | ASC Oran | 2 – 1 (a.e.t.) | CR Belcourt |
| 1981 | DNC Alger | 1 – 0 | EP Sétif | Stade du 1er Novembre 1954, Tizi Ouzou |
Semi-finals edit
| 1981 | MP Oran | 1 – 2 | USK Alger | Stade Akid Lotfi, Tlemcen |