The 50th Tour of Flanders cycling classic was held on Saturday, 9 April 1966. The race was won by Belgian rider Edward Sels in a sprint before Italian Adriano Durante. 60 of 151 riders finished.
The race started in Ghent and finished in Gentbrugge – covering 243 km. For the first time since the 1940s the Kwaremont climbs was not addressed because of road works. There were six categorized climbs:
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