(−)-alpha-cuprenene synthase

(−)-α-Cuprenene synthase (EC 4.2.3.95, Cop6) is an enzyme with systematic name (−)-α -cuprenene hydrolase (cyclizing, (−)-α-cuprenene-forming).[1] This enzyme catalyses the following chemical reaction

(−)-α-cuprenene synthase
Identifiers
EC no.4.2.3.95
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins
(2E,6E)-farnesyl diphosphate (−)-α-cuprenene + diphosphate

The enzyme from the fungus Coprinopsis cinerea produces (−)-α-cuprenene with high selectivity.

References

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  1. ^ Lopez-Gallego F, Agger SA, Abate-Pella D, Distefano MD, Schmidt-Dannert C (May 2010). "Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers". ChemBioChem. 11 (8): 1093–106. doi:10.1002/cbic.200900671. PMC 2873112. PMID 20419721.
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