Randy Schekman
| Randy Wayne Schekman | |
|---|---|
 |
|
| Born | December 30, 1948 Saint Paul, Minnesota |
| Institutions | University of California, Berkeley Howard Hughes Medical Institute Stanford University UCLA |
| Alma mater | Stanford University UCLA |
| Thesis | Resolution and Reconstruction of a multienzyme DNA replication reaction (1975) |
| Doctoral students | David Julius[citation needed] |
| Known for | Editor-in-chief of PNAS[1] and ELife[2] |
| Notable awards | Lasker award (2002) Massry Prize (2010) Foreign Member of the Royal Society (ForMemRS) (2013)[3] |
| Website | |
| mcb.berkeley.edu/labs/schekman royalsociety.org/people/randy-schekman |
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Randy Wayne Schekman (born December 30, 1948) is an American cell biologist at the University of California, Berkeley[4] and former Editor-in-Chief of Proceedings of the National Academy of Sciences.[1][5][6] In 2011 he was announced as the editor of eLife a new high profile open access journal published by the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust launching in 2012.[7] He was elected to the National Academy of Sciences in 1992.[8]
Education
Schekman was award a PhD for research into DNA replication in 1975 from Stanford University.[9]
Research
The Schekman laboratory carries out research into molecular descriptions of the process of membrane assembly and vesicular traffic[10] in eukaryotic cells[11][12] including yeast.[13]
Since 1991, Schekman has been a Howard Hughes Medical Institute Investigator,[14] Division of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology at the University of California, Berkeley
Awards
In 2002, Schekman received the Albert Lasker Award for Basic Medical Research[15] and Louisa Gross Horwitz Prize of Columbia University along with James Rothman for their discovery of cellular membrane trafficking, a process that cells use to organize their activities and communicate with their environment. He was awarded the Massry Prize from the Keck School of Medicine, University of Southern California in 2010. Schekman is also a member of the Selection Committee for Life Science and Medicine which chooses winners of the Shaw Prize.
In 2013 he was elected a Foreign Member of the Royal Society, his nomination read:
"Using a brilliantly conceived genetic screen, Schekman isolated sec mutants that accumulate secretory pathway intermediates, he cloned the corresponding genes and he established biochemical reactions that faithfully reproduced specific secretory pathway events. These studies transformed the secretion field, previously descriptive and morphological, into a molecular and mechanistic one. The cell-free reactions that Schekman established led to his isolation of the Sec61 translocation complex, the (COPII) vesicle coat complex, and the first purified inter-organelle transport vesicles. The Sec proteins are strikingly conserved and the trafficking mechanisms that Schekman discovered are at the heart of neurotransmission, hormone secretion, cholesterol homeostasis and metabolic regulation."[3]
References
- ^ a b Zagorski, N. (2008). "Profile of Randy Schekman: Reflections on his first year as PNAS Editor-in-Chief". Proceedings of the National Academy of Sciences 105 (8): 2763–2765. doi:10.1073/pnas.0610781105. PMC 2268533. PMID 18287009.
- ^ Schekman, R.; Patterson, M. (2013). "Reforming research assessment". ELife 2: e00855. doi:10.7554/eLife.00855.
- ^ a b Professor Randy Schekman ForMemRS
- ^ "Randy Schekman: Howard Hughes Investigator and Professor of Cell and Developmental Biology". Retrieved 2011-07-12.
- ^ Bucci, M. (2006). "Randy Schekman". Nature Chemical Biology 2 (11): 568. doi:10.1038/nchembio1106-568. PMID 17051227.
- ^ Zagorski, N. (2006). "QnAs with Randy Schekman". Proceedings of the National Academy of Sciences 103 (50): 18881. doi:10.1073/pnas.0609700103. PMC 1748144. PMID 17148596.
- ^ "New journal editor named as Randy Schekman | Wellcome Trust". Retrieved 2011-07-12.
- ^ List of publications from Microsoft Academic Search
- ^ Schekman, Randy Wayne (1975). Resolution and Reconstruction of a multienzyme DNA replication reaction (1975) (PhD thesis). Stanford University. http://search.proquest.com/docview/302775556.
- ^ Schekman, R.; Orci, L. (1996). "Coat Proteins and Vesicle Budding". Science 271 (5255): 1526–1533. doi:10.1126/science.271.5255.1526. PMID 8599108.
- ^ "Randy Schekman publications in Google Scholar". Retrieved 2011-07-12.
- ^ Deshaies, R. J.; Koch, B. D.; Werner-Washburne, M.; Craig, E. A.; Schekman, R. (1988). "A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides". Nature 332 (6167): 800–805. doi:10.1038/332800a0. PMID 3282178.
- ^ Novick, P.; Field, C.; Schekman, R. (1980). "Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway". Cell 21 (1): 205–215. doi:10.1016/0092-8674(80)90128-2. PMID 6996832.
- ^ "HHMI Scientist Abstract: Randy W. Schekman, Ph.D.". Retrieved 2011-07-12.
- ^ Malhotra, V.; Emr, S. D. (2002). "Rothman and Schekman SNAREd by Lasker for trafficking". Cell 111 (1): 1–3. doi:10.1016/S0092-8674(02)01008-5. PMID 12372293.
| Academic offices | ||
|---|---|---|
| Preceded by Elizabeth Blackburn |
ASCB Presidents 1999 |
Succeeded by Richard Hynes |
| Preceded by Nicholas R. Cozzarelli |
PNAS editor-in-chief 2006-2011 |
Succeeded by Inder Verma |
| Preceded by - |
eLife editor-in-chief 2013-date |
Succeeded by - |
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