Defending champion Diede de Groot defeated Yui Kamiji in the final, 4–6, 6–1, 6–4 to win the women's singles wheelchair tennis title at the 2019 US Open.
| Wheelchair women's singles | |
|---|---|
| 2019 US Open | |
| Champion |  Diede de Groot |
| Runner-up |  Yui Kamiji |
| Score | 4–6, 6–1, 6–4 |
Seeds edit
Diede de Groot (champion)
Yui Kamiji (final)
Draw edit
Key edit
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Finals edit
| Quarterfinals | Semifinals | Final | ||||||||||||||||||
| 1 | Diede de Groot
| 6 | 6 | |||||||||||||||||
 Sabine Ellerbrock
| 1 | 0 | ||||||||||||||||||
| 1 | Diede de Groot
| 6 | 6 | |||||||||||||||||
| WC |  Dana Mathewson
| 3 | 2 | |||||||||||||||||
 Kgothatso Montjane
| 3 | 6 | 1 | |||||||||||||||||
| WC | Dana Mathewson
| 6 | 0 | 6 | ||||||||||||||||
| 1 | Diede de Groot
| 4 | 6 | 6 | ||||||||||||||||
| 2 | Yui Kamiji
| 6 | 1 | 4 | ||||||||||||||||
| Marjolein Buis
| 6 | 6 | ||||||||||||||||||
 Giulia Capocci
| 1 | 4 | ||||||||||||||||||
| Marjolein Buis
| 1 | 3 | ||||||||||||||||||
| 2 | Yui Kamiji
| 6 | 6 | |||||||||||||||||
| Aniek van Koot
| 1 | 3 | ||||||||||||||||||
| 2 | Yui Kamiji
| 6 | 6 | |||||||||||||||||