Defending champion Diede de Groot and her partner Yui Kamiji defeated the other defending champion Marjolein Buis and her partner Aniek van Koot in the final, 6–3, 6–4 to win the women's doubles wheelchair tennis title at the 2018 US Open. With the win, Kamiji completed the double career Grand Slam.
| Wheelchair women's doubles | |
|---|---|
| 2018 US Open | |
| Champions |  Diede de Groot Yui Kamiji |
| Runners-up | Marjolein Buis Aniek van Koot |
| Score | 6–3, 6–4 |
Seeds edit
Diede de Groot / 
Yui Kamiji (champions)- Marjolein Buis / Aniek van Koot (final)
Draw edit
Key edit
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Bracket edit
| Semifinals | Final | ||||||||||||
| 1 | Diede de Groot Yui Kamiji
| 6 | 6 | ||||||||||
 Sabine Ellerbrock Lucy Shuker
| 0 | 0 | |||||||||||
| 1 | Diede de Groot Yui Kamiji
| 6 | 6 | ||||||||||
| 2 | Marjolein Buis Aniek van Koot
| 3 | 4 | ||||||||||
 Dana Mathewson Kgothatso Montjane
| 1 | 1 | |||||||||||
| 2 | Marjolein Buis Aniek van Koot
| 6 | 6 | ||||||||||