US-101 may refer to:
- U.S. Route 101, a highway that serves the West Coast of the United States
- Lockheed Martin VH-71 Kestrel, U.S. military designation for the AgustaWestland AW101
- WUSY, an FM radio station in Chattanooga, Tennessee
This disambiguation page lists articles associated with the same title formed as a letter–number combination.
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