Tingible body macrophage
A tingible body macrophage is a type of macrophage predominantly found in germinal centers, containing many phagocytized, apoptotic cells in various states of degradation, referred to as tingible bodies (tingible meaning stainable). Tingible body macrophages contain condensed chromatin fragments.
Macrophages that contain debris from ingested lymphocytes are characteristic of a reactive follicular center in benign reactive lymphadenitis. Other accompanying signs of a benign follicular hyperplasia are well developed germinal centers with dark and light zones, in addition to numerous mitotic figures.
- Horst Ibelgaufts' COPE: Cytokines & Cells Online Pathfinder Encyclopaedia > tingible body macrophages Retrieved on June 27, 2010
- MacLennan I.C.M (1994). "Germinal Centers". Annual Review of Immunology. 12: 117–139. doi:10.1146/annurev.iy.12.040194.001001. PMID 8011279.
- Smith JP, Burton GF, Tew JG, Szakal AK (1998). "Tingible body macrophages in regulation of germinal center reactions". Developmental Immunology. 6 (3–4): 285–294. doi:10.1155/1998/38923. PMC 2276033. PMID 9814602.
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