Talk:Cannabinoid receptor 2

12/6/2011 Edits

Before I began editing, these pages were a jumbled mess of confused science and faux-science that had clearly been compiled by recreational marijuana users with minimal understand of how solid research is conducted or reported. Most of the sections were written independently and did not read cohesively when considered by page; as such much of my efforts were spent cleaning up the inconsistencies, miscitations, and straight up fallacies that littered each topic discussed. In addition, I added more citations from appropriate and current research and reorganized the pages so that they are presented in a more digestable format. In summary, these pages on endocannabinoid receptors were not lacking attention before my edits, but had rather received too much attention from people who just did not know what they were talking about. I have simplified, clarified, and expounded where appropriate with the intention of creating a more cohesive and through product. The extent of these edits are subtle, but were based on eight research pages that I read dealing with the topics I addressed — Preceding unsigned comment added by Wyliea (talk • contribs) 01:49, 7 December 2011 (UTC)

Image is misleading

The image ("Rendering based on PDB 2KI9") is not useful or representative in the context of an article about the full receptor. Removing the image would enhance this webpage. The image shows a single helix of a 7-helix bundle. I tried to edit the box, but everything looks auto-generated there, so I left it alone for a more experienced user to tackle.

External links modified

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Background reading

Additional sources, mostly outdated and listed as 'Further reading', are moved here for discussion and/or archiving per WP:ELNO. --Zefr (talk) 15:07, 27 October 2019 (UTC)

• Oddi S, Spagnuolo P, Bari M, D'Agostino A, Maccarrone M (2007). Differential modulation of type 1 and type 2 cannabinoid receptors along the neuroimmune axis. International Review of Neurobiology. Vol. 82. pp. 327–37. doi:10.1016/S0074-7742(07)82017-4. ISBN 978-0-12-373989-6. PMID 17678969.
• Galiègue S, Mary S, Marchand J, Dussossoy D, Carrière D, Carayon P, Bouaboula M, Shire D, Le Fur G, Casellas P (Aug 1995). "Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations". European Journal of Biochemistry / FEBS. 232 (1): 54–61. doi:10.1111/j.1432-1033.1995.tb20780.x. PMID 7556170.
• Munro S, Thomas KL, Abu-Shaar M (Sep 1993). "Molecular characterization of a peripheral receptor for cannabinoids". Nature. 365 (6441): 61–5. doi:10.1038/365061a0. PMID 7689702.
• Shire D, Calandra B, Rinaldi-Carmona M, Oustric D, Pessègue B, Bonnin-Cabanne O, Le Fur G, Caput D, Ferrara P (Jun 1996). "Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor". Biochimica et Biophysica Acta. 1307 (2): 132–6. doi:10.1016/0167-4781(96)00047-4. PMID 8679694.
• Tao Q, McAllister SD, Andreassi J, Nowell KW, Cabral GA, Hurst DP, Bachtel K, Ekman MC, Reggio PH, Abood ME (Mar 1999). "Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity". Molecular Pharmacology. 55 (3): 605–13. PMID 10051546.
• Nong L, Newton C, Friedman H, Klein TW (2002). "CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types". In Friedman H, Klein TW, Madden JJ (eds.). Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases. Advances in Experimental Medicine and Biology. Vol. 493. pp. 229–33. doi:10.1007/0-306-47611-8_27. ISBN 978-0-306-46466-9. PMID 11727770.
• Ho BY, Current L, Drewett JG (Jul 2002). "Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alpha16)". FEBS Letters. 522 (1–3): 130–4. doi:10.1016/S0014-5793(02)02917-4. PMID 12095632.
• Matias I, Pochard P, Orlando P, Salzet M, Pestel J, Di Marzo V (Aug 2002). "Presence and regulation of the endocannabinoid system in human dendritic cells". European Journal of Biochemistry / FEBS. 269 (15): 3771–8. doi:10.1046/j.1432-1033.2002.03078.x. PMID 12153574.
• Song ZH, Feng W (Nov 2002). "Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function". FEBS Letters. 531 (2): 290–4. doi:10.1016/S0014-5793(02)03537-8. PMID 12417328.
• Casanova ML, Blázquez C, Martínez-Palacio J, Villanueva C, Fernández-Aceñero MJ, Huffman JW, Jorcano JL, Guzmán M (Jan 2003). "Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors". The Journal of Clinical Investigation. 111 (1): 43–50. doi:10.1172/JCI16116. PMC 151833. PMID 12511587.
• Feng W, Song ZH (Apr 2003). "Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor". Biochemical Pharmacology. 65 (7): 1077–85. doi:10.1016/S0006-2952(03)00005-4. PMID 12663043.
• Kishimoto S, Gokoh M, Oka S, Muramatsu M, Kajiwara T, Waku K, Sugiura T (Jul 2003). "2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism". The Journal of Biological Chemistry. 278 (27): 24469–75. doi:10.1074/jbc.M301359200. PMID 12711605.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Jorda MA, Rayman N, Valk P, De Wee E, Delwel R (May 2003). "Identification, characterization, and function of a novel oncogene: the peripheral cannabinoid receptor Cb2". Annals of the New York Academy of Sciences. 996: 10–6. doi:10.1111/j.1749-6632.2003.tb03227.x. PMID 12799277.
• Rayman N, Lam KH, Laman JD, Simons PJ, Löwenberg B, Sonneveld P, Delwel R (Feb 2004). "Distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status". Journal of Immunology. 172 (4): 2111–7. doi:10.4049/jimmunol.172.4.2111. PMID 14764676.
• Rao GK, Zhang W, Kaminski NE (May 2004). "Cannabinoid receptor-mediated regulation of intracellular calcium by delta(9)-tetrahydrocannabinol in resting T cells". Journal of Leukocyte Biology. 75 (5): 884–92. doi:10.1189/jlb.1203638. PMID 14966196.
• Alberich Jordà M, Rayman N, Tas M, Verbakel SE, Battista N, van Lom K, Löwenberg B, Maccarrone M, Delwel R (Jul 2004). "The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner". Blood. 104 (2): 526–34. doi:10.1182/blood-2003-12-4357. PMID 15039279.
• Núñez E, Benito C, Pazos MR, Barbachano A, Fajardo O, González S, Tolón RM, Romero J (Sep 2004). "Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study". Synapse. 53 (4): 208–13. doi:10.1002/syn.20050. PMID 15266552.
• Gokoh M, Kishimoto S, Oka S, Mori M, Waku K, Ishima Y, Sugiura T (Mar 2005). "2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells". The Biochemical Journal. 386 (Pt 3): 583–9. doi:10.1042/BJ20041163. PMC 1134878. PMID 15456404.
• Miller, A. M.; Stella, N. (2008). "CB2receptor-mediated migration of immune cells: it can go either way". British Journal of Pharmacology. 153 (2): 299–308. doi:10.1038/sj.bjp.0707523. PMC 2219538. PMID 17982478.
• López EM, Tagliaferro P, Onaivi ES, López-Costa JJ (May 2011). "Distribution of CB2 cannabinoid receptor in adult rat retina". Synapse. 65 (5): 388–92. doi:10.1002/syn.20856. PMID 20803619.