Spi-1 (PU.1) 5′ UTR regulatory element

The Spi-1 (PU.1) 5′ UTR regulatory element is an RNA element found in the 5′ UTR of Spi-1 mRNA which is able to inhibit the translation Spi-1 transcripts by 8-fold.[1] Spi-1 regulates myeloid gene expression during haemopoietic development. Mutations in this regulatory region of the 5′ UTR can lead to overexpression of Spi-1 which has been linked to development of leukaemia.[1]

Spi-1 (PU.1) 5′ UTR regulatory element
Identifiers
SymbolSpi-1
RfamRF00232
Other data
RNA typeCis-reg
Domain(s)Eukaryota
SOSO:0000204
PDB structuresPDBe

See also

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References

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  1. ^ a b Hensold JO, Stratton CA, Barth D (July 1997). "The conserved 5′-untranslated leader of Spi-1 (PU.1) mRNA is highly structured and potently inhibits translation in vitro but not in vivo". Nucleic Acids Research. 25 (14): 2869–2876. doi:10.1093/nar/25.14.2869. PMC 146829. PMID 9207037.
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