Santiago Pérez can refer to:
- Santiago Pérez de Manosalbas (1830-1900), President of Colombia
- Santiago Pérez (racewalker) (born 1972), Spanish racewalker
- Santiago Pérez (baseball) (born 1975), Dominican baseball players
- Santiago Pérez (cyclist) (born 1977), Spanish cyclist
- Santiago Pérez (footballer) (born 1998), Uruguayan footballer
This disambiguation page lists articles about people with the same name.
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