Samuel Holmes may refer to:
- Samuel Jackson Holmes (1868–1964), American zoologist and eugenicist
- Samuel Holmes (politician), speaker of the Illinois House of Representatives during the mid-1850s
- Sam Holmes (baseball) (1915–2010), American baseball player
- Sam Holmes (sailor), American YouTuber and sailor
See also edit
- Samuel Holmes House, Highland Park, Illinois
This disambiguation page lists articles about people with the same name.
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