S66 may refer to:
- S66 (Long Island bus)
- S66 (New York City bus) serving Staten Island
- Awabakal language
- Daihatsu Hijet (S66), a Japanese kei truck
- Explorer S-66, a failed American spacecraft
- Savoia-Marchetti S.66, an Italian flying boat
- S66, a postcode district for Rotherham, England
- Siemens S66, a Siemens mobile phone
This disambiguation page lists articles associated with the same title formed as a letter–number combination.
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