SH2 may stand for:
- SH2 (classification), a Paralympic shooting classification
- SH2 domain (Src Homology 2), a protein domain within the Src oncoprotein
- SH-2 Seasprite, an American-built ship-based helicopter
- SH-2, an iteration of the SuperH CPU core developed by Hitachi
- Shadow Hearts: Covenant, also known as Shadow Hearts II
- Silent Hill 2, a 2001 survival horror video game, or its 2024 remake
- State Highway 2, see List of highways numbered 2
This disambiguation page lists articles associated with the same title formed as a letter–number combination.
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