Region 5 or Region V can refer to:
- One of DVD region codes
- Region 5, Northwest Territories
- One of health regions of Canada managed by Vitalité Health Network
- Former Region 5 (Johannesburg), an administrative district in the city of Johannesburg, South Africa, from 2000 to 2006
- One of Regions of Iran
- Valparaíso Region, Chile
- Bicol Region, Philippines
This disambiguation page lists articles associated with the title Region 5.
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