Queen of the South may refer to:

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Arts, entertainment, and media edit

  • The Queen of the South (novel), the English title of La Reina del Sur, a 2002 Spanish novel by Arturo Pérez-Reverte
  • "Queen of the South", a song by the Scottish record producer Bill Drummond on the 1986 album The Man
  • "Queen of the South", a song on the 1993 album Liberation by The Divine Comedy

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