The 2010 Central American and Caribbean Games ((in Spanish) "XXI Juegos Centroamericanos y del Caribe - Mayagüez 2010") will be held in Mayagüez, Puerto Rico, from July 17, 2010 to August 1, 2010. It's the third time Puerto Rico hosts the Central American and Caribbean Games, the other being San Juan in 1966, and Ponce in 1993. The city of Mayagüez had been selected previously to hold the games in 1982, but economic problems forced the city to quit the organization, and the games were held in La Habana, Cuba.

A total of 4,965 athletes will participate in 39 sports to be held across Puerto Rico, Colombia, Guatemala, and Guyana. The opening ceremony will be held on July 17, 2010 in Mayagüez Central American Stadium.