Pinc (pregnancy induced noncoding RNA) is a long non-coding RNA. It was originally identified in the mammary glands of oestrogen and progesterone-treated rats.[1] Pinc may be a mammal-specific gene. It is conserved in a number of mammalian genomes (human, mouse, rat, chimpanzee, dog, cow and opossum), but not in fugu, zebrafish or xenopus genomes.[2]

Pregnancy induced noncoding RNA
Identifiers
Organismmouse
SymbolPinc
Entrez723792
RefSeq (mRNA)NR_003202
Other data
Chromosome1: 73.44 - 73.45 Mb

In mice, Pinc is expressed in the developing embryo and in the mammary glands of adults. Its expression in the mammary gland is induced by pregnancy and drops during lactation. It may have a role in cell survival and in the regulation of cell cycle progression.[2]

See also

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References

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  1. ^ Ginger MR, Gonzalez-Rimbau MF, Gay JP, Rosen JM (November 2001). "Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland". Mol. Endocrinol. 15 (11): 1993–2009. doi:10.1210/mend.15.11.0724. PMID 11682629.
  2. ^ a b Ginger MR, Shore AN, Contreras A, et al. (April 2006). "A noncoding RNA is a potential marker of cell fate during mammary gland development". Proc. Natl. Acad. Sci. U.S.A. 103 (15): 5781–5786. Bibcode:2006PNAS..103.5781G. doi:10.1073/pnas.0600745103. PMC 1420634. PMID 16574773.

Further reading

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