Oligosaccaryltransferase

(Redirected from OST4)

In molecular biology, OST4 (Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit 4) is a subunit of the oligosaccharyltransferase complex.[1] OST4 is a very short, approximately 30 amino acids, protein found from fungi to vertebrates. It appears to be an integral membrane protein that mediates the en bloc transfer of a pre-assembled high-mannose oligosaccharide onto asparagine residues of nascent polypeptides as they enter the lumen of the rough endoplasmic reticulum.[2][3]

Oligosaccaryltransferase
nmr structure of yeast oligosaccharyltransferase subunit ost4p
Identifiers
SymbolOst4
PfamPF10215
InterProIPR018943
OPM superfamily242
OPM protein2lat
Membranome465
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

References

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  1. ^ Kelleher DJ, Gilmore R (2006). "An evolving view of the eukaryotic oligosaccharyltransferase". Glycobiology. 16 (4): 47R–62R. doi:10.1093/glycob/cwj066. PMID 16317064.
  2. ^ Gayen S, Kang C (2011). "Solution structure of a human minimembrane protein Ost4, a subunit of the oligosaccharyltransferase complex". Biochem Biophys Res Commun. 409 (3): 572–6. doi:10.1016/j.bbrc.2011.05.050. PMID 21609714.
  3. ^ Spirig U, Bodmer D, Wacker M, Burda P, Aebi M (2005). "The 3.4-kDa Ost4 protein is required for the assembly of two distinct oligosaccharyltransferase complexes in yeast". Glycobiology. 15 (12): 1396–406. doi:10.1093/glycob/cwj025. hdl:20.500.11850/30954. PMID 16096346.
This article incorporates text from the public domain Pfam and InterPro: IPR018943

Chi, J.H., Roos, J. and N. Dean. (1996) The OST4 gene of Saccharomyces cerevisiae encodes an unusually small protein required for normal levels of oligosaccharyltransferase activity J. Biol. Chem. 271;3132-3140.