O22 or O-22 may refer to:
- Columbia Airport (California)
- Douglas O-22, an observation aircraft of the United States Army Air Corps
- HNLMS O 22, a submarine of the Royal Netherlands Navy
- Otoyol 22, a motorway in Turkey
- Oxygen-22, an isotope of oxygen
This disambiguation page lists articles associated with the same title formed as a letter–number combination.
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