Miles O'Brien may refer to:
- Miles O'Brien (journalist) (born 1959), news journalist
- Miles M. O'Brien (1852–1910), banker and former president of the New York City Board of Education
- Miles O'Brien (Star Trek), a fictional character from Star Trek: The Next Generation and Star Trek: Deep Space Nine, played by Colm Meaney
This disambiguation page lists articles about people with the same name.
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