Eileen O'Brien may refer to:
- Eileen O'Brien (actress), English actress
- Eileen O'Brien (journalist) (1925-1986), Irish journalist
- Eileen O'Brien (camogie), Irish camogie player
- Eileen O'Brien (baseball) (1922–2015), played in the All-American Girls Professional Baseball League in 1946
- Eileen O'Brien, musician, daughter of accordionist Paddy O'Brien
This disambiguation page lists articles about people with the same name.
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