Donough O'Brien may refer to:
- Donough O'Brien (author) (born 1939), marketing, public relations executive and author
- Donough O'Brien (cricketer) (1879–1953), Welsh-born Irish cricketer
- Sir Donough O'Brien, 1st Baronet (1642–1717), Irish politician and baronet
- Donough O'Brien, 16th Baron Inchiquin (1897–1968)
- Donough O'Brien, 2nd Earl of Thomond (died 1553)
- Donogh O'Brien, 4th Earl of Thomond (died 1624)
- Donough O'Brien (died 1582)
See also
edit- Donnchad mac Briain (died 1064), 11th-century king of Munster
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