Donald O'Brien may refer to:
- Donald O'Brien (actor) (1930–2003), French-born Italian film and television actor
- Donald E. O'Brien (1923–2015), U.S. district judge
- Domnall Mór Ua Briain (died 1194), King of Thomond in Ireland (1168–1194)
This disambiguation page lists articles about people with the same name.
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