Christopher O'Brien may refer to:
- Christopher O'Brien (admiral), Irish naval officer of the eighteenth century
- Christopher D. O'Brien (1848–?), former mayor of St. Paul, Minnesota
- Christopher O'Brien (rugby league) (born 1950), Welsh rugby union and rugby league footballer of the 1970s and 1980s
See also
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This disambiguation page lists articles about people with the same name.
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