Chris O'Brien may refer to:
- Chris O'Brien (American football) (1881–1951), owner of the Chicago Cardinals and co-founder of the National Football League
- Chris O'Brien (baseball) (born 1989), minor league baseball player
- Chris O'Brien (rugby) (born 1950), Welsh rugby league player
- Chris O'Brien (surgeon) (1952–2009), Australian oncologist and surgeon
- Chris O'Brien (rugby union) (born 1964), United States rugby union player
See also
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This disambiguation page lists articles about people with the same name.
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