James Needham may refer to:
- James Needham (explorer) (died 1673), explorer in America
- James Needham (mycologist) (1849–1913), English working-class mycologist
- James C. Needham (1864–1942), U.S. Representative from California
- James George Needham (1868–1957), American entomologist
This disambiguation page lists articles about people with the same name.
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