This disambiguation page lists articles associated with the title Luis de Velasco.
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The name Luis de Velasco can refer to:
- Don Luis (active 1561–1571), a Native American also known as Paquiquino (named for the following at baptism)
- Luís de Velasco (1511–1564), second viceroy of New Spain
- Luis de Velasco, 1st Marquess of Salinas (c.1534–1617), son of the previous
- Luis de Velasco y Velasco, 2nd Count of Salazar (1559–1625), son of the previous
- Luis Vicente de Velasco (1711–1762), naval commander
- Luis de Velasco Rami (born 1939), Spanish economist