Inoviridae is a family of bacteriophage viruses. The genomes are composed of circular single-stranded DNA. Bacteria serve as natural hosts. There are, as of 2014[update], 43 defined species in this family, divided between two genera. However, mining of genomic and metagenomic datasets using machine learning approach led to the discovery of 10,295 inovirus-like sequences in nearly all bacterial phyla across virtually every ecosystem, indicating that this group of viruses is much more diverse and widespread than originally appreciated.
Viruses in Inoviridae are non-enveloped, with rod or filament geometries. The diameter is around 7 nm, with a length of 2000 nm. Genomes are circular, around 8 kb in length. The genome codes for 4 to 10 proteins.
|Genus||Structure||Symmetry||Capsid||Genomic arrangement||Genomic segmentation|
Viral replication is cytoplasmic. Entry into the host cell is achieved by pilus-mediated adsorption into the host cell. Replication follows the ssDNA rolling circle model. DNA-templated transcription is the method of transcription. The virus exits the host cell by viral extrusion. Bacteria serve as the natural host.
|Genus||Host details||Tissue tropism||Entry details||Release details||Replication site||Assembly site||Transmission|
|Inovirus||Gram-negative bacteria||None||Pilus adsorption||Secretion||Cytoplasm||Cytoplasm||Pilus|
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