Hepatitis C virus cis-acting replication element

The Hepatitis C virus (HCV) cis-acting replication element (CRE) is an RNA element which is found in the coding region of the RNA-dependent RNA polymerase NS5B. Mutations in this family have been found to cause a blockage in RNA replication and it is thought that both the primary sequence and the structure of this element are crucial for HCV RNA replication.[1]

Hepatitis C virus (HCV) cis-acting replication element (CRE)
Predicted secondary structure and sequence conservation of HepC_CRE
Identifiers
SymbolHepC_CRE
RfamRF00260
Other data
RNA typeCis-reg
Domain(s)Viruses
SOSO:0000233
PDB structuresPDBe

See also

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References

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  1. ^ You S, Stump DD, Branch AD, Rice CM (February 2004). "A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replication". Journal of Virology. 78 (3): 1352–1366. doi:10.1128/JVI.78.3.1352-1366.2004. PMC 321395. PMID 14722290.
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