Guadalupe District may refer to:
Peru edit
- Guadalupe District, Pacasmayo, in Pacasmayo province, La Libertad region
Costa Rica edit
- Guadalupe District, Zarcero, in the canton of Zarcero, Alajuela province
- Guadalupe o Arenilla District, Cartago , in the canton of Cartago, Cartago province
- Guadalupe District, Goicoechea, in the canton of Goicoechea, San José province