Georges J. F. Köhler
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Georges Jean Franz Köhler
César Milstein and Georges Jean Franz Köhler
|Born||April 17, 1946|
|Died||March 1, 1995 (aged 48)|
|Known for||monoclonal antibodies|
|Awards||Nobel Prize in Physiology or Medicine in 1984|
|Institutions||Max Planck Institute of Immunobiology|
|Doctoral advisor||Fritz Melchers|
Together with César Milstein and Niels Kaj Jerne, Köhler won the Nobel Prize in Physiology or Medicine in 1984, "for work on the immune system and the production of monoclonal antibodies". Milstein and Köhler's technique for producing monoclonal antibodies laid the foundation for the exploitation of antibodies for diagnostics and therapeutics and many scientific applications.
In April 1974 Köhler took up a post-doctoral research fellowship at the Laboratory of Molecular Biology in Cambridge, UK where he began working with César Milstein to develop a laboratory tool that could help them investigate the mechanism that underlies the diversity of antibodies. It was during this work that they devised their hybridoma technique for the production of antibodies. Köhler continued his collaboration on the technique when he returned to Basel Institute of Immunology in April 1974. Köhler remained at the Basel Institute for another nine years, during which time he continued investigating antibody diversity and in the early 1980s began working on the development of transgenic mice as a tool to understand the mechanism that underlies self-tolerance. In 1986 Köhler became director of the Max Planck Institute of Immunobiology where he worked until his death in 1995.
- The Story of César Milstein and Monoclonal Antibodies.
- K. Eichmann, Köhler's Invention (Birkhäuser Verlag, Basel, 2005) University of Freiburg Faculty of Biology
- G. Köhler & C. Milstein (1975). "Continuous cultures of fused cells secreting antibody of predefined specificity". Nature. 256 (5517): 495–7. Bibcode:1975Natur.256..495K. doi:10.1038/256495a0. PMID 1172191.
- István Hargittai (2006). "Köhler's Invention". Journal Structural Chemistry. 17 (1): 161–162. doi:10.1007/s11224-006-9042-0.
- Melchers, F (1995). "Georges Köhler (1946-95)". Nature. 374 (6522) (published Apr 6, 1995). p. 498. Bibcode:1995Natur.374..498M. doi:10.1038/374498a0. PMID 7700372.
- Danon, Y L (1996). "[Monoclonal antibodies: George Kohler]". Harefuah. 130 (2) (published Jan 15, 1996). pp. 108–9. PMID 8846970.
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