George Grimes may refer to:
- George Grimes (American football) (1922–1971), NFL football player for the Detroit Lions
- George Grimes (English politician) (1605–1657), member of parliament and Royalist
- George Grimes (Queensland politician) (1835–1910), member of the Queensland Legislative Assembly
- George F. Grimes (1877–1929), businessman and political figure in Newfoundland
This disambiguation page lists articles about people with the same name.
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