Frederick of Hesse may refer to:
- Frederick, Landgrave of Hesse-Eschwege (1617–1655)
- King Frederick I of Sweden (1676–1751), Landgrave of Hesse
- Frederick II, Landgrave of Hesse (1720–1785)
- Prince Frederick of Hesse (1747–1837), Danish general, third son of Frederick II, Landgrave of Hesse
- Prince Frederik of Hesse (1771–1845), Danish general, son of Prince Charles of Hesse and nephew of previous
- Frederick William of Hesse (1820–1884), second cousin of previous, and his titular successor since 1875
- Frederick William III, Landgrave of Hesse (1854–1888), eldest son of the previous
- Alexander Frederick of Hesse (1863–1945), brother of the previous
- Prince Frederick Charles of Hesse (1868–1940), Landgrave of Hesse and elected King of Finland
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