Francesco Piccolomini may refer to:
- Pope Pius III (1439–1503), born Francesco Todeschini Piccolomini
- Francesco Piccolomini (1582–1651), Italian Jesuit
- Francesco Piccolomini (died 1622), bishop of Grosseto
- Francesco Piccolomini (1523–1607), professor of natural philosophy
This disambiguation page lists articles about people with the same name.
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