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Summary
| Description |
English: Schematic of membrane fusion mediated by paramyxovirus fusion proteins. After the prefusion form of the fusion protein (A) is triggered, the coiled-coil HRB domain melts leading to the formation of the open stalk form (B). The FP is then projected towards the target membrane and HRA refolds to a trimeric coiled coil (pre-hairpin intermediate, C). HRB then translocates toward HRA, forcing the viral membrane and the target membrane into a hemifusion state (D). The complete refolding of HRB around HRA forms the stable 6HB and allows for the formation of the fusion pore (E). Blue: FP, Orange: HRA, Green: HRB, Red: TM. |
| Date | |
| Source |
Chang, A.; Dutch, R.E. Paramyxovirus Fusion and Entry: Multiple Paths to a Common End. Viruses 2012, 4, 613-636. https://doi.org/10.3390/v4040613 |
| Author | Andres Chang and Rebecca E. Dutch |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 10:23, 5 February 2021 | | 1,000 × 231 (130 KB) | Guest2625 | Uploaded a work by Andres Chang and Rebecca E. Dutch from Chang, A.; Dutch, R.E. Paramyxovirus Fusion and Entry: Multiple Paths to a Common End. Viruses 2012, 4, 613-636. https://doi.org/10.3390/v4040613 with UploadWizard |
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