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File:Signal transduction v1.png

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Description

Signal transduction pathways. Picture is a new version of old figure self-made in illustrator.

Date (original upload date)
Source Originally from {Molecular cell biology. Lodish, Harvey 5 ed: - New York : W. H. Freeman and Co., 2003, 973 s. b ill. ISBN: 0-7167-4366-3. Libris: 8926100. The Hallmarks of Cancer, Douglas Hanahan and Robert A. Weinberg, Cell, Vol. 100, 57–70, January 7, 2000. http://www.weizmann.ac.il/home/fedomany/Bioinfo05/lecture6_Hanahan.pdf
Author Roadnottaken at English Wikipedia
Other versions

Derivative works of this file: Signal transduction pathways (zh-cn).svg

Involved proteins and Wikipedia links

--> = stimulation
--| = inhibition

Pathways involved:

en:Growth factors
-->RTK en:Receptor tyrosine kinase
-->en:Grb2, SOS en:Son of Sevenless
-->en:Ras
-->Raf
-->MEK en:MAPK/ERK kinase
-->en:MAPK --> Jun, en:Mad:Max
-->ERK
-->Fos en:C-fos

MEK --> en:MEKK
--> en:Myc:Max

PLC en:phospholipase C
-->PKC en:protein kinase c
-->Raf

en:Ras
-->en:Cdc42
-->en:Rac
-->en:Rho

Mos en:c-Mos
-->MEK en:MAPK/ERK kinase

ECM en:Extracellular matrix
-->en:Integrins

Integrins
-->en:Cdc42
-->en:PI3K
-->en:Rac
-->en:JNK
-->Jun

Integrins
-->en:FAK Src
-->Cas en:CRK-associated substrate
-->en:CRK

Integrins
-->Fyn Shc en:Src homology 2 domain-containing
-->en:Ras

MKKs
-->en:JNKs

Hormones,
e.g.
en:bombesin
-->en:7TM-receptor
-->G-prot en:G-protein
-->en:Ras, en:PI3K, Ad cycl en:Adenylate cyclase
-->PKA en:protein kinase A
-->en:CREB

e.g. en:estrogen
-->en:NHR

Survival factors
e.g.
en:IGF1
-->RTK en:Receptor tyrosine kinase
-->en:PI3K
-->PKC en:Protein kinase C
-->en:NF-kB

PI3K
-->en:Akt
-->Akka en:Akk-alpha
-->en:IκB
-->NF-kB

Cytokines
-->Cytokine R en:Cytokine-Receptor
-->en:Jaks
-->Stats
-->Bcl XL
--|en:cytochrome c

Abnormality sensor e.g.
Bim
-->Mt en:Mitochondria
-->en:cytochrome c
-->casp9 en:caspase 9
-->en:apoptosis

Akt
--|Bad en:Bcl-2-associated death promoter
--> Mt en:Mitochondria

en:Decoy Receptor
--|en:Death factors

e.g.
FasL en:Fas ligand
-->Fas
-->en:FADD
-->en:caspase 8
-->apoptosis

caspase 8
-->en:Bld
-->Mt en:Mitochondria
-->apoptosis

FAP en:Fas-associated phosphatase
--|Fas

Changes in gene expression
-->ARF
--|en:MDM2
--|en:p53
-->Bax
-->Mt en:Mitochondria
-->apoptosis

Antigrowth factors
e.g.
en:TGFβ
-->TGFβR en:TGFβ receptors
-->en:Smads
-->p15, p27]], p21

p15
--|cycl D en:Cyclin D CDK4 en:Cyclin-dependent kinase 4
--|Rb en:Retinoblastoma protein
--|en:E2F

p21
--|cycl E en:Cyclin E CDK2 en:Cyclin-dependent kinase 2

en:HPVE7 --|Rb en:Retinoblastoma protein

Hedgehog
--|Patched
-->en:Smoothened
-->Gil
-->Changes in gene expression

en:Sufu
--> Gil

Wnt
-->en:Frizzled
-->Dishevelled
-->en:GSK-3β
-->APC
-->en:β-catenin

β-catenin + TCF en:T-cell factor
--> Gene expression

Licensing

Roadnottaken at the English language Wikipedia, the copyright holder of this work, hereby publishes it under the following license:
GNU head Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled GNU Free Documentation License.
w:en:Creative Commons
attribution share alike
This file is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license.
Attribution: Roadnottaken
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must attribute the work in the manner specified by the author or licensor (but not in any way that suggests that they endorse you or your use of the work).
  • share alike – If you alter, transform, or build upon this work, you may distribute the resulting work only under the same or similar license to this one.
This licensing tag was added to this file as part of the GFDL licensing update.

Original upload log

(All user names refer to en.wikipedia)

  • 2007-03-22 23:24 Roadnottaken 1858×1364×8 (259189 bytes) new version of old figure. self-made in illustrator. contact me for .AI file ~~~~
  • 2007-03-22 23:18 Roadnottaken 1858×1364×8 (258214 bytes) fixed error in old figure. self-made in illustrator. (contact me for .AI file) ~~~~
  • 2007-03-22 23:14 Roadnottaken 1858×1364×8 (251473 bytes) new version of old figure self-made in illustrator.

File history

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Date/TimeThumbnailDimensionsUserComment
current11:20, 27 May 2007Thumbnail for version as of 11:20, 27 May 20071,858 × 1,364 (253 KB)ChaosCreated by w:User:Roadnottaken , he putted it under GFDL see [http://en.wikipedia.org/wiki/Image:Signal_transduction_v1.png] {{GFDL-user-w|en|En Wikipedia|Roadnottaken}} {{GFDL}}

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