File:Schematic visualization of endocytic routes adopted by various GPI-Anchored proteins and other endocytic markers.jpg
Size of this preview: 169 × 598 pixels. Other resolutions: 67 × 240 pixels | 135 × 480 pixels | 1,007 × 3,563 pixels.
Original file (1,007 × 3,563 pixels, file size: 523 KB, MIME type: image/jpeg)
 | This is a file from the Wikimedia Commons. Information from its description page there is shown below. Commons is a freely licensed media file repository. You can help. |
| Description |
English: Schematic visualization of endocytic routes adopted by various GPI-Anchored proteins and other endocytic markers. A) Various membrane resident proteins and lipids like FR-GPI, prions, LRP, uPAR, cholesterol, sphingolipids and cholera-toxin bound to GM1 are present in a diffuse distribution in the plasma membrane. B) GPI-APs like FR-GPI align with cholesterol and sphingolipids to form lateral aggregates termed as rafts. uPAR and prion proteins, although GPI-anchored, interact with LRP and are endocytosed into the clathrin-coated pits. The interaction of the protein domains of uPAR and Prion with LRP seems to override the influence of the lateral segregation into rafts mediated by the GPI-anchor of these proteins. LRP has signal sequences in the cytoplasmic domain for recruitment into clathrin-coated pits. C and D) Raft-included markers like FR-GPI and cholera toxin bound to GM1 are endocytosed into GEECs whereas uPAR:LRP and prion;LRP complexes are endocytosed into vacuoles derived from clathrin-coated pits. Lakhan et al. Journal of Biomedical Science 2009 16:93 doi:10.1186/1423-0127-16-93 |
| Date | |
| Source | Endocytosis of glycosylphosphatidylinositol-anchored proteins |
| Author | Shaheen E Lakhan , Shefali Sabharanjak and Ananya De |
| Permission (Reusing this file) |
© 2009 Lakhan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
This file is licensed under the Creative Commons Attribution 2.0 Generic license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 18:50, 22 October 2009 | | 1,007 × 3,563 (523 KB) | CopperKettle | {{Information |Description={{en|1=Schematic visualization of endocytic routes adopted by various GPI-Anchored proteins and other endocytic markers. A) Various membrane resident proteins and lipids like FR-GPI, prions, LRP, uPAR, cholesterol, sphingolipids |
File usage
No pages on the English Wikipedia use this file (pages on other projects are not listed).
Global file usage
The following other wikis use this file:
- Usage on ca.wikipedia.org
- Usage on ru.wikipedia.org
