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File:Schematic of RNA timestamp workflow, 4 steps.png

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English: The first step is for the RNA of interest to be tagged with the timestamp. Next, as the time stamp is transcribed, the adenosine rich repeat regions (editing array) slowly are converted to inosines by ADARcd2 (depicted as ADAR). ADAR is bound to the MS2 binding sites of the timestamp. The accumulation of A-to-I edits can be read through sequencing technologies such as RNA-seq. (This image is an original work with some elements having been adapted from the work of Rodriques, S.G., Chen, L.M., Liu, S. et al. RNA timestamps identify the age of single molecules in RNA sequencing. Nat Biotechnol 39, 320–325 (2021). https://doi.org/10.1038/s41587-020-0704-z)
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A workflow schematic of RNA timestamps represented in 4 steps.

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3 March 2021

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current16:25, 24 March 2021Thumbnail for version as of 16:25, 24 March 20211,190 × 481 (112 KB)Elizabethstephens21Uploaded own work with UploadWizard

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