Size of this preview: 627 × 599 pixels. Other resolutions: 251 × 240 pixels | 502 × 480 pixels | 803 × 768 pixels | 1,071 × 1,024 pixels | 1,362 × 1,302 pixels.
Original file (1,362 × 1,302 pixels, file size: 1.83 MB, MIME type: image/png)
 | This is a file from the Wikimedia Commons. Information from its description page there is shown below. Commons is a freely licensed media file repository. You can help. |
Summary
| Description |
English: Model of the retromer heterotrimer consisting of VPS26 (dark green), VPS35 (light orange) and VPS29 (red), which form a polymeric network of arches that wraps around the outer (cytoplasmic) side of the tubule. Inside the tubule, the large ectodomain of SORL1 forms a supporting polymeric network by dimerizing via two distinct interfaces. The two networks are connected through the transmembrane domain of SORL1 and its short C-terminal tail; the tail binds to VPS26(A or B) on the outside of the tubule. SORL1 thus not only serves as a cargo receptor; it is also an internal part of the retromer assembly, and helps to stabilize the self-association of retromer. The data used to construct this model came from the cryoET structure of retromer on the membrane, determined in Prof. Brett Collins' lab, and the model of the ectodomain of SORL1, constructed in Prof. Greg Petsko's lab by Dr. Yu Kitago. The proposed mode of dimerization of SORL1 is based on experimental work by Dr. Kitago and Prof. Olav Andersen, and is described in Jensen et al., PNAS (2023). |
| Date | |
| Source | Own work |
| Author | SimonCotter |
Licensing
I, the copyright holder of this work, hereby publish it under the following license:
This file is licensed under the Creative Commons Attribution-Share Alike 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 14:12, 19 July 2023 | | 1,362 × 1,302 (1.83 MB) | SimonCotter | Uploaded own work with UploadWizard |
