Size of this preview: 800 × 301 pixels. Other resolutions: 320 × 120 pixels | 640 × 241 pixels | 1,578 × 594 pixels.
Original file (1,578 × 594 pixels, file size: 116 KB, MIME type: image/jpeg)
 | This is a file from the Wikimedia Commons. Information from its description page there is shown below. Commons is a freely licensed media file repository. You can help. |
Summary
| Description |
English: Schematic of defined domains of NEDD9, including SH3, unstructured substrate domain (SD), serine rich (SR) four- helix bundle domain, and C-terminal focal adhesion targeting (FAT) domain containing a Src-binding region (SB). Diagram indicates some (not all) defined interactors with NEDD9, proximal to defined association motifs. These include the kinase FAK, which binds the SH3 domain. The SD contains multiple YxxP motifs, which are phosphorylated by Src-family kinases such as Fyn, Lck and Src to create binding sites for proteins with SH2 domains, such as Crk. Kinase Aurora-A binds NEDD9 and phosphorylates serine 296 in the SD, supporting mitotic activities. The FAT-like domain interacts with NSP and other proteins, and contributes to NEDD9 targeting to focal adhesions. |
| Date | |
| Source | Own work |
| Author | Gaponova Anna |
Licensing
I, the copyright holder of this work, hereby publish it under the following license:
This file is licensed under the Creative Commons Attribution-Share Alike 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 04:56, 31 July 2017 | | 1,578 × 594 (116 KB) | Evolution and evolvability | cropped out unnecessary text |
| 21:46, 16 January 2015 |  | 1,578 × 807 (271 KB) | Gaponova Anna | User created page with UploadWizard |
File usage
The following pages on the English Wikipedia use this file (pages on other projects are not listed):
Global file usage
The following other wikis use this file:
