Chloroxine (trade name Capitrol; Kloroxin, Dichlorchinolinol, chlorquinol, halquinol(s));[citation needed] Latin cloroxinum, dichlorchinolinolum) is an antibacterial drug.[1] Oral formulations (under trade name such as Endiaron[2]) are used in infectious diarrhea, disorders of the intestinal microflora (e.g. after antibiotic treatment), giardiasis, inflammatory bowel disease. It is also useful for dandruff and seborrheic dermatitis.,[3] as used in shampoos (Capitrol) and dermal creams like (Valpeda, Triaderm).
Clinical data | |
---|---|
Trade names | Capitrol |
Other names | cloroxinum, kloroxin, chlorquinol, dichlorchinolinolum, halquinol(s) |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
ATC code |
|
Legal status | |
Legal status |
|
Identifiers | |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.011.144 |
Chemical and physical data | |
Formula | C9H5Cl2NO |
Molar mass | 214.05 g·mol−1 |
3D model (JSmol) | |
| |
|
Mechanism of action edit
Chloroxine has bacteriostatic, fungistatic, and antiprotozoal properties. It is effective against Streptococci, Staphylococci, Candida, Candida albicans, Shigella, and Trichomonads.[citation needed]
Adverse effects edit
Rarely occurs, but may cause nausea and vomiting associated with oral administration. It may also cause skin irritation.[citation needed]
Pregnancy and lactation edit
The FDA lists chloroxine in Pregnancy Category C (risk cannot be ruled out) because no pregnancy studies on the medication have been performed with animals or humans. For this reason, use of chloroxine oral or topical during pregnancy or when breast-feeding is not recommended.[4]
History edit
Chloroxine was first prepared in 1888 by A. Hebebrand.[citation needed]
References edit
- ^ Pharmaceutical Manufacturing, Books.Google.com
- ^ Endiaron.cz
- ^ Chloroxine, drugs.com
- ^ Capitrol - FDA prescribing information Archived 2018-11-24 at the Wayback Machine, drugs.com