Domestic Science Building may refer to:
- Domestic Science Building (Normal, Alabama), listed on the National Register of Historic Places in Madison County, Alabama
- Domestic Science Building (Arkadelphia, Arkansas), NRHP-listed
- Girls' Domestic Science and Arts Building, Russellville, Arkansas, NRHP-listed
- Domestic Science and Manual Training School, St. Petersburg, Florida, NRHP-listed
This disambiguation page lists articles associated with the title Domestic Science Building.
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