DeSoto High School can refer to:
- DeSoto High School (Texas), DeSoto, Texas
- De Soto High School (Kansas), De Soto, Kansas
- De Soto High School (Wisconsin), De Soto, Wisconsin
- De Soto High School (Missouri), De Soto, Missouri
See also
edit- DeSoto Central High School, Southaven, Mississippi
- DeSoto County High School, Arcadia, Florida
- North DeSoto High School, Stonewall, Louisiana
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