Crucifixion thorn may refer to one of the following North American desert plants:

  • Canotia holacantha, a shrub or small tree in the family Celastraceae native to the Mojave and Sonoran Deserts
  • Castela emoryi, a shrub or small tree in the family Simaroubaceae native to the Mojave and Sonoran Deserts
  • Castela erecta (goatbush), a shrub or small tree in the family Simaroubaceae native to the Chihuahuan Desert
  • Colletia cruciata
  • Holacantha stewartii (Stewart crucifixion-thorn), a shrub or small tree in the family Simaroubaceae native to the Chihuahuan Desert
  • Koeberlinia spinosa (allthorn), a shrub or small tree in the family Koeberliniaceae native to the Sonoran Desert