Clement Clay may refer to:
- Clement Comer Clay (1789–1866), Governor of Alabama 1835–1837, and U.S. Senator from Alabama 1837–1841
- Clement Claiborne Clay (1816–1882), son of Clement Comer Clay; U.S. Senator from Alabama 1853–1861, and Confederate States senator from Alabama 1861–1863
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