James Clarkson may refer to:
- James Clarkson (footballer) (born 1972), English-American head coach of the Houston Dash
- James S. Clarkson (1842–1918), American Republican National Committee chairman
- James A. Clarkson (1906–1970), American mathematician
- Buster Clarkson (1915–1989), American baseball player
This disambiguation page lists articles about people with the same name.
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